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KMID : 0545120100200060985
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Journal of Microbiology and Biotechnology
2010 Volume.20 No. 6 p.985 ~ p.987
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Biotransformation of Bioactive (?)-Mellein by a Marine Isolate of Bacterium Stappia sp
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Feng Zhile
Nenkep Viviane N.
Yun Keum-Ja
Zhang Dahai
Choi Hong-Dae
Kang Jung-Sook
Son Byeng-Wha
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Abstract
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The biological transformation of the bioactive dihydroisocoumarin, (?)-mellein (1), isolated from the marine-derived fungus Cladosporium sp., was studied. The preparative-scale culture of 1 with a marine isolate of a bacterium Stappia sp. resulted in the isolation of its oxidized metabolite, (3R,4S)-4-hydroxymellein (2). The stereostructure of the metabolite obtained was assigned on the basis of detailed physicochemical data analyses.
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KEYWORD
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Biotransformation, dihydroisocoumarin, (?)-mellein, (3R, 4S)-4-hydroxymellin, Stappia sp
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